Soliman, Beatrice et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2019 | CAS: 954-81-4

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 954-81-4

Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors was written by Soliman, Beatrice;Wang, Ning;Zagotto, Giuseppe;Pockes, Steffen. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Related Products of 954-81-4 This article mentions the following:

Imidazolylbutyl cyanoguanidines, such as N-cyano-N’-4-(4-imidazolyl)butyl-N”-2-(phenylthio)ethylguanidine, previously identified as highly potent agonists at the human histamine H4 receptor (hH4R), display certain drawbacks in pharmacokinetics, which led to the attempt to replace the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Besides these changes, a variation of the spacer length (C3-C5) connecting the heterocycle and the cyanoguanidine moiety was made to possibly trigger the selectivity towards the resp. HRs. Investigations in radioligand-binding assays of the synthesized compounds I [X = CH2, O, S, NMe; Y = CH2, S; Z = (CH2)n; n = 1-3] exhibited only very weak activity at the hH1R and hH3R, while nearly all compounds were inactive at the hH2R and hH4R. In the case of piperidine-containing compounds, moderate affinities at the hH3R over the single-digit micromolar range were detected. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary