Synthesis of oligo-6-bromo-6-deoxy-β-cyclodextrins was written by Kurochkina, G. I.;Trushkin, I. Yu.;Grachev, M. K.;Nifant’ev, E. E.. And the article was included in Russian Journal of General Chemistry in 2004.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:
Two methods of synthesis of oligo-6-bromo-6-deoxy-β-cyclodextrins, with use of the Vilsmeier-Haack reagent and via tosyl derivatives of β-cyclodextrin, were compared. The second method holds more promise, since it allows a desired number of bromine atoms to be introduced into the β-cyclodextrin mol. instead of hydroxy groups. A correlation between the decomposition onset points of oligo-6-bromo-6-deoxy-β-cyclodextrins and the number of bromine substituents in them was revealed. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary