Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression was written by Yestrepsky, Bryan D.;Xu, Yuanxi;Breen, Meghan E.;Li, Xiaoqin;Rajeswaran, Walajapet G.;Ryu, Jenny G.;Sorenson, Roderick J.;Tsume, Yasuhiro;Wilson, Michael W.;Zhang, Wenpeng;Sun, Duxin;Sun, Hongmin;Larsen, Scott D.. And the article was included in Bioorganic & Medicinal Chemistry in 2013.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:
Resistance to antibiotics is an increasingly dire threat to human health that warrants the development of new modes of treating infection. The authors recently identified CCG-2979 as an inhibitor of the expression of streptokinase, a critical virulence factor in Group A Streptococcus that endows blood-borne bacteria with fibrinolytic capabilities. The authors describe the synthesis and biol. evaluation of a series of novel 5,6-dihydrobenzo[h]quinazolin-4(3H)-one analogs of CCG-2979 undertaken with the goal of improving the modest potency of the lead. In addition to achieving an over 35-fold increase in potency, the authors identified structural modifications that improve the solubility and metabolic stability of the scaffold. The efficacy of two new compounds CCG-203592 and CCG-205363 against biofilm formation in Staphylococcus aureus represents a promising addnl. mode of action for this novel class of compounds In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary