Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate was written by Lin, Biyue;Kou, Jingping;Xiao, Qingbo;Wu, Shuming;Hu, Ji’an;Li, Jianbing;Zhu, Zhu;Zhou, Xinglin;Xin, Libo;Li, Yanhua;Wang, Zhongqing. And the article was included in Tetrahedron in 2022.Formula: C5H4BrNO This article mentions the following:
A first synthetic research concerning four observed metabolites and their deuterium-labeled analogs of reflux esophagitis drug vonoprazan fumarate was reported. Among which the synthetic methods of three metabolites M – I, M-III, M-IV-Sul, and four stable isotop labeled analogs M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 was not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Formula: C5H4BrNO).
5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C5H4BrNO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary