Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD was written by Liu, Anqiu;Huang, Ling;Wang, Zhiren;Luo, Zonghua;Mao, Fei;Shan, Wenjun;Xie, Jiaxing;Lai, Kefang;Li, Xingshu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.SDS of cas: 954-81-4 This article mentions the following:
A novel class of dual pharmacol. bronchodilators I(n = 2, 3, 4, 5) and II(n = 1, 3, 4, 5) targeting both β2-adrenoceptor and PDE4 was designed and synthesized by combining the pharmacophores of salmeterol and roflumilast or phthalazinone. All the compounds exhibited better β2-adrenoceptor agonist activities (pEC50 = 8.47-9.20) than the reference compound salmeterol (pEC50 = 8.3) and good inhibitory activity on PDE4B2 (IC50 = 0.235-1.093 μM). In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4SDS of cas: 954-81-4).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.SDS of cas: 954-81-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary