Parameters of the production of carboxin and its analogs was written by Dziedzic, Czeslaw;Eckstein, Zygmunt;Ejmocki, Zdzislaw;Miszczak, Kamila;Rusek, Dorota;Tippe, Andrzej. And the article was included in Przemysl Chemiczny in 1983.Application of 615-55-4 This article mentions the following:
Chlorinating MeCOCH2CO2Et (I) with SOCl2 in C6H6 gave 98.1-9.9% MeCOCHClCO2Et, which condensed with HSCH2CH2OH in the presence of NaHCO3 to give the intermediate HOCH2CH2SCH(CO2Et)COMe. Cyclocondensation of the latter in the presence of acid gave ester II (R = OEt), which was saponified to give 47.6-51.8% II (R = OH) (III), based on I. Treating III with SOCl2 and then PhNH2 and 34 other primary and secondary aromatic and heterocyclic amines yielded 21.0-98.8% II (R = substituted NH2). The fungicidal activity of II (R = NHC6H4R1; R1 = C1-C5 alkoxy, F) exceeded that of II (R = NHPh). In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application of 615-55-4).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application of 615-55-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary