Copper-catalyzed annulation of 2-bromobenzoic esters with terminal alkynes towards 3-substituted isocoumarins was written by Sun, Mengli;Su, Lebin;Dong, Jianyu;Liu, Long;Zhou, Yongbo;Yin, Shuang-Feng. And the article was included in Tetrahedron Letters in 2017.Recommanded Product: Methyl 2-bromo-4-fluorobenzoate This article mentions the following:
An efficient method for the synthesis of 3-substituted isocoumarins that are an important class of biol. active scaffolds via annulation of 2-bromobenzoic esters with terminal alkynes using copper catalyst was described. The advantages of this method included mild reaction conditions, high yield and regioselectivity, and wide tolerance toward functional groups. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Recommanded Product: Methyl 2-bromo-4-fluorobenzoate).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: Methyl 2-bromo-4-fluorobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary