Brief introduction of 4333-56-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bromocyclopropane, its application will become more common.

Application of 4333-56-6,Some common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, molecular formula is C3H5Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 36; 1-bromo-3-cyclopropoxybenzene A mixture of 3-bromophenol (2.4g, 13.9mmol), bomocyclopropane (6.66ml, 83mmol) and potassium carbonate (9.6g, 69.5mmol) in DMF (16ml) was heated at 18O0C in a microwave oven for 8 hours. The reaction mixture was diluted with a mixture of diethylether and water. The organic layer was separated, washed with water, brine, dried over Na2SO4, filtered and evaporated. An oil was obtained, 2.87g, with a purity of 81%. This intermediate was used for the next reaction. Retention time: 6.91 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bromocyclopropane, its application will become more common.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2008/77639; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary