In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 327-51-5 as follows. COA of Formula: C6H2Br2F2
Compound A-14 (24.6 g, 74 mmol), 1, 4-dibromo-2, 5-difluorobenzene (20 g, 74 mmol), and a 2 M aqueous solution of Na2CO3 (75 mL, 150 mmol), DME (150 mL), toluene (150 mL), and Pd [PPh3]4 (4.3 g, 3.7 mmol) were loaded into a three-necked flask, and the mixture was refluxed under an Ar atmosphere for 8 hours. After the completion of the reaction, the resultant was cooled to room temperature. The resultant sample was transferred to a separating funnel, and water (100 mL) was charged into the funnel. Then, the mixture was extracted with CH2Cl2. The extract was dried with MgSO4, and was then filtrated and concentrated. The resultant sample was purified by silica gel column chromatography, whereby a white solid was obtained in an amount of 21 g in 60% yield. FD-MS C24H13BrF2N2O2: theoretical value 479, observed value 479
According to the analysis of related databases, 327-51-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2301921; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary