Synthetic Route of 17247-58-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17247-58-4, name is (Bromomethyl)cyclobutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(5-Bromo-7-methyl-l-oxo-l,3-dihydiO-isoindol-2-yl)-carbamic acid tert-butyl ester (0.05g, 0.146 mmol), bromomethyl cyclobutane (0.033 mL, 0.293 mmol) and cesium carbonate (0.12 g, 0.366 mmol) were stirred in acetonitrile (3 mL) at 70 0C for 3 hours. The reaction mixture was partitioned with dichloromethane and water and the aqueous phase was further extracted with dichloromethane. The organic extracts were washed with water, brine, dried over sodium sulfate, filtered and concentrated. The product residue was purified by eluting through a solid phase extraction tube eluting with ethyl acetate:hexanes (2:98 to 5:95) to yield the product as a colorless oil (0.048 g, 80%). 1H NMR (300 MHz, CDCI3): 5 7.39 (d, 2H), 6.71 (br s, IH), 4.46 (s, 2H), 2.68 (s, 3H), 1.42 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclobutane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2008/130853; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary