In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 586-61-8 as follows. 586-61-8
To fuming nitric acid (5 mL) cooled to 5 was added neat 4-bromoisopropylbenzene(1.0 g, 5.023 mmol) dropwise at such a rate that the reaction temperature remained below 10. The reaction was stirred for 2 hours at 5-10, quenched with ice (50 g), extracted with ethyl acetate (50 mL), and the organic extract was washed with water (2×25 mL) and brine (25 mL), then dried over magnesium sulfate. filtered and concentrated by rotary evaporation. The residue was purified by silica gel flash chromatography eluting with 5:95 ethyl acetate/hexanes to afford the title compound as a light yellow solid (1.03 g, 4.22 mmol, 84%). 1H NMR (300 MHz, CHLOROFORM-D) delta ppml.27 (d, J=6.99 Hz, 6 H) 2.75 – 3.23 (m, 1 H) 7.29 (dd, J=8.82, 2.21 Hz, 1 H) 7.63 (d, J=8.09 Hz, 1 H) 7.69 (d, J=2.21 Hz, 1 H); MS (DCI) m/z 261/263 (M+NH4)+.
According to the analysis of related databases, 586-61-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; WO2008/133753; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary