Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Monos, Timothy M., once mentioned the application of 506-26-3, Name is (6Z,9Z,12Z)-Octadeca-6,9,12-trienoic acid, molecular formula is C18H30O2, molecular weight is 278.43, MDL number is MFCD00065718, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of (6Z,9Z,12Z)-Octadeca-6,9,12-trienoic acid.
Continuous-Flow Synthesis of Tramadol from Cyclohexanone
A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. ‘Flash’ reactivity between meta -methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g degrees h (-1) ) sustained over 56 reactor volumes. A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 506-26-3, Quality Control of (6Z,9Z,12Z)-Octadeca-6,9,12-trienoic acid.