327-51-5, The chemical industry reduces the impact on the environment during synthesis 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, I believe this compound will play a more active role in future production and life.
Example 9 Synthesis of Compound 31 In a 1,000-mL three-necked flask were placed 8.0 g (27.8 millimoles) of 2-carbazolylphenylboronic acid, 4.0 g (12.8 millimoles) of 1,4-dibromo-2,5-difluorobenzene, and 1.6 g (1.4 millimoles) of tetrakis(triphenylphosphine)palladium(0), then 75 mL of ethanol and 150 mL of toluene were added, and the mixture was stirred. Thereafter, a solution of 14.3 g (135.0 millimoles) of sodium carbonate in 150 mL of water was thrown into the flask. The mixture was then heated to 80C and stirred for 17 hours. The reaction solution was cooled to room temperature, transferred to a 1,000-mL separatory funnel, and separated into an organic layer and an aqueous layer. The organic layer was washed three times with 200 mL of water and then dehydrated over magnesium sulfate, the magnesium sulfate was filtered off, and the solvent was distilled off under reduced pressure. The reaction mixture thus obtained was purified by recrystallization from THF and methanol to yield 5.1 g of Compound 31 as a white solid; EI-MS, 597 (M+1); melting point, 263C; glass transition temperature, 92C.
The chemical industry reduces the impact on the environment during synthesis 1,4-Dibromo-2,5-difluorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Nippon Steel Chemical Co., Ltd.; EP2272828; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary