86845-27-4, These common heterocyclic compound, 86845-27-4, name is 5-Bromo-2-methylbenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00478] To a solution of 4-bromo-1-methyl-2-(trifluoromethyl)benzene (6 g, 25.1 mmol), 2-Di-t-butylphosphino-2′,4′,6′-tri-i-propyl-1, -biphenyl (848 mg, 2.0 mmol), Pdidbas (4.6 g, 5.0 mmol) and KOH (4.2 g, 75.3 mmol) in dioxane (40 mL) and water (40 mL) under N2. The mixture was stirred at 100 C for 2.5 h. The reaction was quenched with ice-water, the pH adjusted to 5 with I N HCl aqueous solution, extracted with EtOAc, washed with brine, dried over sodium sulfate, concentrated and purified by chromatography (silica, DCM/petroleum ether=l/2) to afford 4-methyl-3-(trifluoromethyl)phenol (3.5 g, 79 %) as a white solid. ESI-MS (EI+, m/z): No mass
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 86845-27-4.
Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary