Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21865-50-9, name is 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H12BrN
To a solution of 6-bromo-2,3,4,9-tetrahydro-lH-carbazole (150 mg, 0.61 mmol) inDMF (5 ml) was added NaH (60% in mineral oil, 37 mg, 0.92 mmol) and tetrabutylammonium iodide (340 mg, 0.92 mmol). The resulting mixture was stirred at room temperature for 10 min and followed by addition of l-(3-chloropropoxy)-3,5- dimethylbenzene (121 mg, 0.61 mmol). The reaction mixture was stirred at room temperature overnight, poured into H2O (30 ml), and extracted with EtOAc (3 x 30 ml). The organic layers were combined, dried over MgSO4, filtered and cone, in vacuo. The crude product was purified by silica gel flash chromatography (EtOAc/hexane, 0-20%) to give the title compound (colorless oil, 182 mg). The yield: 72.4%.
The synthetic route of 21865-50-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ITHERX PHARMACEUTICALS, INC.; WO2009/103022; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary