Reference of 90562-10-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90562-10-0 name is 1-Bromo-4-(3-bromopropyl)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compounds 2 (40 mg, 0.14 mmol) and 7 (27.6 mg, 0.15 mmol) were dissolved in 1.5 mL of acetonitrile and then potassium carbonate (20.7 mg, 0.15 mmol) was added to the solution. After reflux for 1 h, potassium carbonate was removed by filtration. The solvent was removed in vacuo. The residue was purified by chromatography on silica gel using chloroform-methanol (40:1) as the eluent to obtain compound 9 (52 mg, 94%) as a colorless powder. 1H NMR (400 MHz, CDCl3): delta 1.10-1.32 (m, 4H), 1.65-1.85 (m, 5H), 2.07-2.25 (m, 2H), 2.35-2.55 (m, 6H), 2.34 (t, J=7.6 Hz, 2H),2.58 (t, J=7.6 Hz, 2H), 2.70-2.80 (m, 2H), 3.30-3.40 (m, 1H), 3.90-4.05 (m, 1H), 7.05 (d, J=7.8 Hz, 2H), 7.39 (d, J=7.8 Hz, 2H). HRMS (DART) m/z calcd for C19H30BrN2O (M+H)+, 381.1542; found 381.1548.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-(3-bromopropyl)benzene, and friends who are interested can also refer to it.
Reference:
Article; Ogawa, Kazuma; Masuda, Ryohei; Mishiro, Kenji; Wang, Mengfei; Kozaka, Takashi; Shiba, Kazuhiro; Kinuya, Seigo; Odani, Akira; Bioorganic and Medicinal Chemistry; vol. 27; 10; (2019); p. 1990 – 1996;,
Bromide – Wikipedia,
bromide – Wiktionary