2270-59-9, name is 5-Bromo-2-methylpent-2-ene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-Bromo-2-methylpent-2-ene
To a solution of 1- ( 6-Amino-9H-purin-8-yl) -3, 6, 6- trimethyl-1, 5, 6, 7-tetrahydro-indazol-4-one (0.0327 g, 0.105 mmol) in DMF (1 mL) are added Cs2CO3 (0.041 g, 0.126 mmol) , and5-bromo-2-methyl-2-pentene (0.02 mL, 0.126 mmol). The reaction mixture is stirred at RT for 1 day. The resulting precipitate is removed by vaccum filtration, and the filtrate is evaporated under reduced pressure. Purification of the crude material using a Biotage column (10 – 70% EtOAc/hexanes for 10 CV) affords 0.0113 g of 1- [ 6-Amino-9- (4-methyl-pent-3- enyl) -9H-purin-8-yl] -3, 6, 6-trimethyl-l, 5, 6, 7-tetrahydro- indazol-4-one (28%) . LC/MS Calculated for C21H27N7O: m/z = 393. Found: m/z = 394 [M+H]+.
The synthetic route of 2270-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SERENEX, INC.; WO2008/24981; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary