In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 630-17-1 as follows. Computed Properties of C5H11Br
To a suspension of magnesium turnings (15.42 g, 634 mmol) and iodine (3 tablets) in anhydrous diethyl ether (10 ml) was added neopentyl bromide (77 ml, 601 mmol) dropwise over 2 hr under nitrogen at room temperature ) In dry ether (290 ml) was added dropwise to maintain a slight reflux, and then the mixture was refluxed for 1 hr and then allowed to cool to room temperature. The resulting Grignard reagent was added dropwise to a solution of 3-bromobicyclo [4.2.0] octa-1,3,5-trien-7-one (100 g, 510 mmol) in dry ether (1000 ml) In order to maintain the internal temperature ~ 0 c. The reaction mixture was allowed to warm to room temperature overnight, then it was cooled to 0 C, quenched with dilute hydrochloric acid (340 ml, 2 M aq) and allowed to warm to room temperature. The organic phase was washed with water (3 x 120 ml), dried over MgSO4 and the solvent was removed under reduced pressure to yield an orange oil (134 g). The oil was purified by silica gel plugs (eluted with hexane: ethyl acetate (95: 5%) to give the title product as a mixture of two isomers in an orange oil (111.1 g, 0.40 mol, 78% , 91.8% purity by 4 NMR).
According to the analysis of related databases, 630-17-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL CO., LTD.; KAMTEKAR, KIRAN; BOURCET, FLORENCE; ZUBERI, TANIA; KUGLER, THOMAS; (75 pag.)TW2016/5767; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary