630-17-1, name is 1-Bromo-2,2-dimethylpropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Bromo-2,2-dimethylpropane
l-(2,2-dimethylpropyI)-4-fluoro-S-methoxy-3-met yl-l,3-dihydro-2H-benzimidazol~2-one (7-5)A solution of 7-fluoro-6-methoxy-l -methyl- 1 ,3 -dihydro-2H-benzimidazol-2-one (7-4, 250 mg, 1.27 mmol) in anhydrous DMF (1.5 ml) was treated with NaH and l-Bromo-2,2- dimethylpropane. The reaction was then irradiated in a microwave at 175 deg C for 25 min. The reaction was partitioned between EtOAc (2×60 ml) and water (75 ml). The combined organic layers were dried over Na2S04 and concentrated, affording the title compound, 1 -(2,2- dimethylpropyl)-4-fluoro-5-methoxy-3-methyl-l,3-dihydro-2H-benzimidazol-2-one (7-5), as an orange oil. 1HNMR (300 MHz, CDC13) delta 6.65-6.70 (m, 2H), 3.88 (s, 3H), 3.60 (m, 5H)} 1.03 (s, 9H). LRMS m/z Calc’d for Ci4Hi9FN202 (M+H) 267.3, found 267.0.
The synthetic route of 630-17-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DUDKIN, Vadim; FRALEY, Mark, E.; ARRINGTON, Kenneth, L.; LAYTON, Mark, E.; RODZINAK, Kevin, J.; PERO, Joseph, E.; REIF, Alexander, J.; WO2012/21382; (2012); A1;,
Bromide – Wikipedia,
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