According to the analysis of related databases, 4333-56-6, the application of this compound in the production field has become more and more popular.
Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4333-56-6, name is Bromocyclopropane, This compound has unique chemical properties. The synthetic route is as follows., name: Bromocyclopropane
Intermediate 54: (2S)-Lambda/-r(S)-cvclopropyl(phenv?methyll-3-methyl-1-r(trimethylsilyl)oxyl- 2-butanamine; EPO Cyclopropyl bromide (4.64g, 38.4mmole) was dissolved in dry Et2O (50ml) under argon, cooled to -780C and treated with tert-BuLi (45ml_ of a 1.7M solution in pentane, 76.5mmole). After 10 minutes, cooling was removed and the mixture stirred at room temperature for 1 hr. After re-cooling to -4O0C, a solution of Intermediate 52 (8.43g, 32mmole) in dry Et2O (40ml) was added and stirring continued at -4O0C for 1.5 hrs. 5M HCI acid was added (50ml) and the phases separated. The aqueous phase was washed with Et2O (discarded) and then basified with KOH pellets to pH >10 in the presence of Et2O. The organic phase was washed with water and brine and then evaporated to dryness under vacuum to afford the title compound as a colourless oil (6.42g, 86%); 1 HNMR (400MHz, CDCI3) delta 0.13 – 0.15, (1 H, m), 0.34 – 0.37, (2H1 m), 0.60 – 0.70, (1 H, m), 0.83, (3H, d, J = 7Hz), 0.91 , (3H, d, J = 7Hz), 0.98 – 1.00, (1 H, m), 1.71 – 1.77, (1 H, m), 2.44 – 2.48, (1 H, m), 3.00, (1 H, d, J = 8Hz), 3.32 and 3.36, (1 H, dd, J = 5 and 11 Hz), 3.59 and 3.61 , (1 H, dd, J = 5 and 11 Hz), 7.25 – 7.42, (5H, m); m/z(APCI): 234.2 [M+H]+.
According to the analysis of related databases, 4333-56-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/50992; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary