Related Products of 10016-52-1, The chemical industry reduces the impact on the environment during synthesis 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.
The second scheme: to 250 ml three-mouth bottle adding 2.36g (3.8 × 10-3Mol) precursor 3 (through the implementation of example three preparation) and 0.5g (1.53 × 10-3Mol) 2, 8 – dibromodiphenyl benzofuran, adding 100g toluene. Opening stirring, system for the picture and the turbid, N2Replacement system 10min. In the system by adding 0.37g (3.84 × 10-3Mol) tertiary butyl alcohol sodium, 0.045g (6.14 × 10-5Mol) Pd (dppf) Cl2And 0.025g (1.24 × 10-4Mol) tri-butyl phosphine, 110 C reaction 20 hours. The said technological, cooling to 20 – 25 C, the reaction liquid filtration, filtrate directly filtering of the silica gel column, eluting with toluene, the solvent under reduced pressure, the crude product shall be light brown red foam. In the above-mentioned crude product is added n-hexane and toluene recrystallization (mass ratio of 4:1), gain the light yellow powdery product 1.7g, yield: 65%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CECEP Wanrun Co., Ltd.; Ren Huicai; Pang Maoyin; Yang Fushan; Tian Shaozhen; Shi Rujin; Hu Baohua; (14 pag.)CN105153085; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary