Synthetic Route of 1435-51-4, These common heterocyclic compound, 1435-51-4, name is 1,3-Dibromo-5-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
l,3-Dibromo-5-fluorobenzene (10.2 g, 40.7 mmol) was dissolved in 1,4- dioxane. Pyridine-4-ylboronic acid (5 g, 40.7 mmol), tetrakis(triphenylphosphine)- palladium(O) (462 mg, 0.41 mmol), and K2CO3 (11.22 g, 81 mmol) were added, and the mixture was heated at 900C for 4 h. The reaction was diluted with EtOAc, washed with aq. NaHCO3 and dried and removed. Purification via column chromatography afforded 4-(3-bromo-5-fluorophenyl)pyridine (6 g, 59%). 1H NMR (400 MHz, CDCl3): delta 8.73 (d, IH), 8.58 (d, IH), 7.77 (dd, IH), 7.45 (s, IH), 7.34-7.31 (m, IH), 7.22 (t, IH), 7.18- 7.15 (m, IH).
Statistics shows that 1,3-Dibromo-5-fluorobenzene is playing an increasingly important role. we look forward to future research findings about 1435-51-4.
Reference:
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
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