Related Products of 7051-34-5,Some common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, molecular formula is C4H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Hydroxybenzaldehyde (3.00 g, 0.0246 mol), bromomethylcyclopropane (3.58 ml, 0.0369 mol) and K2CO3 (6.8 g, 0.050 mol) were taken in acetone (80 ml) and refluxed for 24 h. The reaction mixture was cooled to room temperature, the insolubles filtered through Celite and the solvent was evaporated to obtain a crude residue. Purification of the residue by column chromatography (silica gel 60-120 mesh, EtOAc:Hexane 0.5:9.5) afforded 3.6 g (83.14%) of 4-cyclopropylmethoxybenzaldehyde. LCMS [M+H]+ 177.0 IH-NMR (CDCl3): 9.877 (s, IH), 7.813-7.833 (d, 2H, J=8 Hz), 6.984-7.004 (d, 2H, J=8 Hz), 3.882-3.899 (d, 2H, J= 6.8 Hz), 1.259-1.295 (m, IH), 0.669-.687 (m, 2H), 0.383 (bs, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Bromomethyl)cyclopropane, its application will become more common.
Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; SARMA, Pakala, Kumara Savithru; ACHARYA, Vinod, Parameshwaran; KASIBHATLA, Srinivas, Rao; VISWANADHAN, Vellarkad, Narayana; SHEKHAR, Polisetti; BISCHOFF, Alexander; WO2010/127212; (2010); A1;,
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