Electric Literature of 7745-91-7,Some common heterocyclic compound, 7745-91-7, name is 3-Bromo-4-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The substituted amines (2mmol) and triethylamine were taken in THF (20mL) and anhydrous potassium carbonate was added (600mg) to it. A solution of 3 (2mmol), in THF (10mL) was added drop wise with stirring for 30min. The reaction mixture was refluxed for 10h. After completion of the reaction (TLC), the reaction mixture was then desolventized in rotavapor and the compound is extracted in dichloromethane. The dichloromethane layer was washed with water and dried over anhydrous Na2SO4 and further desolventization in rotary evaporator to get the desired compound. Structure verification data for novel compounds are documented in Supplementary File.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-4-methylaniline, its application will become more common.
Reference:
Article; Prashanth; Madaiah; Revanasiddappa; Veeresh; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 110; (2013); p. 324 – 332;,
Bromide – Wikipedia,
bromide – Wiktionary