In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2606-51-1 as follows. Recommanded Product: 2606-51-1
Boc-L-Pyroglutamic acid methyl ester (1.05 g, 4.32 mmol) was dissolved in dry THF (20mL). The mixture was cooled to -78 C. LiHMDS (1 M in THF, 4.40 mL, 4.40 mmol) was addeddropwise at -78 C over 10 minutes. The solution was stirred at -78 C for 1 hour. A solution of 5-(bromomethyl)-1 ,3-benzodioxole (0.975 g, 4.53 mmol) in dry THF (5 mL) was then added dropwise at -78 C over 30 minutes. The solution was stirred at -78 C for 2 hours. Sat. NaHCO3 (aq) (40 mL) was added dropwise with continual stirring until the solution reached room temperature. The mixture was diluted with EtOAc (50 mL) and the layers separated. The organic phase was washed with sat. brine (aq) (40 mL) then dried (Mg504), filtered and the solvent evaporated in vacuo. The crudeproduct was purified by flash chromatography (Biotage Isolera; 50 g SNAP cartridge) eluting with isohexane -* 40% EtOAc – isohexane to yield the title compound (1.08 g, 66 %) as a white solid.AnalpH2_MeOH_4MIN: Rt: 3.03 mi mlz 378.3 [M+H]+
According to the analysis of related databases, 2606-51-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF LEEDS; PHILIPPOU, Helen; FOSTER, Richard; FISHWICK, Colin; REVILL, Charlotte; YULE, Ian; TAYLOR, Roger; NAYLOR, Alan; FALLON, Philip, Spencer; CROSBY, Stuart; HOPKINS, Anna; GUETZOYAN, Lucie, Juliette; MACNAIR, Alistair, James; STEWART, Mark, Richard; WINFIELD, Natalie, Louise; (273 pag.)WO2019/186164; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary