Reference of 38573-88-5,Some common heterocyclic compound, 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, molecular formula is C6H3BrF2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compounds of the formula (I-7-1) A reaction vessel 10.0 g (0.052 mol), 1- pentyne 4.6 g(0.067 mol), copper iodide (I) 0.20g (1 .0 mmol), was added N, N-dimethylformamide 120 mL,triethylamine 40 mL. After the inside of the system was replaced with nitrogen, tetrakis(triphenylphosphine) palladium (0) 0.60 g (0.52 mmol) was added and heating for 12 hoursstirring at 90 ° C. After dilution with toluene, hydrochloric acid, washed with brine, and purifiedby column chromatography (silica gel) to give the formula (the I-7-2) with the compoundrepresented by 7.0 g (0.039 mol) .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,3-difluorobenzene, its application will become more common.
Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; KUSUMOTO, TETSUO; (71 pag.)JP2015/78153; (2015); A;,
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