In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 452-63-1 as follows. Recommanded Product: 452-63-1
A screw-capped vial (8 mL) was charged with compound 538 (100 mg, 0.37 MMOL) in 1,4-dioxane (2 mL), 2-bromo-5-fluoro-toluene (55 LULL, 0.44 MMOL), CS2C03 (169 mg, 0.52 MMOL), PD2 (dba) 3 (9 mg, 0.009 MMOL), and rac-BINAP (9 mg, 0.014 MMOL). The tube was capped with a rubber septum, flushed with argon for 5 min, and then stirred at 100 C for 18 h. The reaction mixture was allowed to cool to room temperature, and then poured into a mixture of water and EtOAc. The aqueous phase was extracted twice with more EtOAc. The combined organic phases were washed with brine, dried (MgS04), filtered and concentrated in vacuo. The crude product was purified by chromatography eluting with EtOAc/petroleum ether 1: 3 to afford the title compound as light brown oil.
According to the analysis of related databases, 452-63-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LEO PHARMA A/S; WO2005/9940; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary