These common heterocyclic compound, 10269-01-9, name is (3-Bromophenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks
General procedure: A mixture of 1,3-dione (1.5 mmol) and benzylamine (1.5 mmol) was stirred in refluxing EtOH (78 C) for 2 hrs under air. The reaction progress was monitored by TLC. After completion of the reaction, the mixture was cooled to 10 C. Crystalline solid was filtere out. No further purification was needed.
The synthetic route of (3-Bromophenyl)methanamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sarkar, Rajib; Mukhopadhyay, Chhanda; Tetrahedron Letters; vol. 59; 32; (2018); p. 3069 – 3076;,
Bromide – Wikipedia,
bromide – Wiktionary