Related Products of 29086-41-7,Some common heterocyclic compound, 29086-41-7, name is 1,1-Bis(bromomethyl)cyclopropane, molecular formula is C5H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 1 .78 g (4.80 mmol) of compound 2-1 and 2.2 g (9.7 mmol) of 1 ,1 -bis(bromomethyl)cyclopropane in 20 mL of DMSO was added 3.2 g (9.7 mmol) of CS2CO3. The mixture was stirred at rt for 3 h under argon atmosphere, then diluted with 50 mL of water and extracted with four 100 mL portions of ethyl acetate. The combined organic layers were washed with brine and dried over anhydrous Na2S04. After filtration, the filtrate was concentrated under reduced pressure to afford a residue, which was purified by silica gel column chromatography eluting with 0 to 15 % gradient of EtOAc in PE to afford compound 6-1. LC-MS: m/e = 324 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1-Bis(bromomethyl)cyclopropane, its application will become more common.
Reference:
Patent; ANGEX PHARMACEUTICAL, INC.; WU, Wen-Lian; YANG, Zhiqiang; LEE, Francis; TAN, John Qiang; (112 pag.)WO2019/94143; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary