Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 656-64-4, name is 3-Bromo-4-fluoroaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 656-64-4
A solution of DCl (10 mmol) was added dropwise to a solution of 3-bromo-4-fluoroaniline (1.8 g, 10 mmol) in diethyl ether (10 mL) at 0C, and stirred at room temperature for 20 minutes. After a solid appeared, it was filtered andwashed with diethyl ether to give 1.9 g solid. 20 mL of deuterated water was added and the reaction was reacted undermicrowave at 150C for 1 hour. The reaction mixture was cooled to room temperature, neutralized with saturated sodiumbicarbonate solution, and extracted with dichloromethane. The organic phase was collected to obtain 1.2 g of a yellowsolid with a yield of 67%. LC-MS (APCI): m/z = 192.0 (M+1)+; 1H NMR (300 MHz, DMSO-d6) (delta/ppm) 6.98 (d, J = 9.0Hz, 1H), 5.20 (br s, 2H).
The synthetic route of 656-64-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; LI, Huanyin; (30 pag.)EP3398942; (2018); A1;,
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