Reference of 402-43-7, A common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, molecular formula is C7H4BrF3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
i-Butyl piperazine-l-carboxylate (1.52 g, 8.17 mmol, 2.00 equiv), l-bromo-4- (trifluoromethyl)benzene (1 g, 4.10 mmol, 1.00 equiv), BINAP (124 mg, 0.40 mmol, 0.10 equiv), Pd2(dba)3 (184 mg, 0.20 mmol, 0.05 equiv), NaOi-Bu (1.2 g, 12.50 mmol, 3.00 equiv), and toluene (15 mL) were combined in a 100-mL round- bottom flask, stirred overnight at 100C in an oil bath, and concentrated under vacuum. Purification by silica gel column with PE/EA (50:1) yielded 1.06 g (78%) of i-butyl 4-(4-(trifluoromethyl)phenyl)piperazine-l-carboxylate as a yellow solid.LC-MS (ES, m/z): 331 [M+H]+
The synthetic route of 402-43-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael; WO2011/28947; (2011); A2;,
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