1647-26-3, name is 1-Bromo-2-cyclohexylethane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 1647-26-3
General procedure: To a solution of the corresponding hydroxyl indanone compound 7b-g (1.67mmol) in DMF (10mL), K2CO3 (3.35mmol) and appropriate alkyl or phenyl bromide (1.84mmol) were added. The resulting solution was stirred at 60C until complete conversion of the starting material (3h). After cooling to ambient temperature, the reaction mixture was concentrated under reduced pressure and diluted with ethyl acetate. The organic phase was washed with water, brine solution, dried over anhydrous Na2SO4, and then concentrated under reduced pressure. The residue was subjected to flash silica gel (230-400 mesh) column chromatography (eluting with 0-20% ethyl acetate in hexanes) to afford the title compounds.
The synthetic route of 1647-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Boggu, Pulla Reddy; Cho, Jungsuk; Kim, Youngsoo; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 152; (2018); p. 65 – 75;,
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