Application of 40161-54-4, A common heterocyclic compound, 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, molecular formula is C7H3BrF4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 43: N-(5-Fluorothiazol-2-yl)-5-(2-(5-methyl-lH-imidazol-l-yl)-4- (trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(lH)-sulfonamide Step 1 : l-(2-Bromo-5-(trifluoromethyl)phenyl)-5-methyl-lH-imidazole A solution of 4-methyl-lH-imidazole (1.352 g, 16.46 mmol) in 20 mL THF was treated with lithium tert-butoxide IN in hexane (16.46 ml, 16.46 mmol) and was allowed to stir for one hour. The reaction mixture was concentrated and then transferred to a microwave vial charged with l-bromo-2-fluoro-4-(trifluoromethyl)benzene (2.360 ml, 16.46 mmol) and 10 mL dioxane. The reaction mixture was heated to 180 C in a microwave reactor for one hour. After cooling to room temperature, the reaction mixture was poured into saturated NH4CI solution and was extracted with DCM. The organics were concentrated, then purified directly by silica gel column chromatography (0 to 50% EtO Ac/heptane) yielding l-(2- bromo-5-(trifluoromethyl)phenyl)-5-methyl-lH-imidazole (0.710 g, 2.327 mmol).
The synthetic route of 40161-54-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
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