New learning discoveries about 17247-58-4

Synthetic Route of 17247-58-4, These common heterocyclic compound, 17247-58-4, name is (Bromomethyl)cyclobutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0079] Step G: l-[2-(2,4-Dichloro-phenyl)-ethyl]-8-(3-methoxy-phenyl)-l,3- diaza-spiro[4.5]decane-2,4-dione 86 (0.52 g, 1.16 mmol), bromomethylcyclobutane (0.175 mL, 1.56 mmol) and potassium carbonate (0.32 g, 2.32 mmol) in dry DMSO (5.0 mL) are stirred for 3 h at 500C. The mixture is cooled to rt, diluted with water and extracted with DCM (3x). The combined extracts are washed with 1 N HCl, H2O (3x) and brine, dried over MgSO4, and concentrated to afford 3-cyclobutylmethyl-l-[2-(2,4-dichloro-phenyl)-ethyl]-8- (3-methoxy-phenyl)-l,3-diaza-spiro[4.5]decane-2,4-dione 87 (0.65 g, quant.) as a clear, thick oil: MS calcd. for C28H33Cl2N2O3 (MH-H+) 515.1, found 515.1; 1H-NMR (400 MHz, CDCl3) delta = 7.40 (d, J= 1.7 Hz, IH), 7.21 (m, 3H), 6.88 (d, J = 7.9 Hz, IH)5 6.83 (t, J= 2.2 Hz, IH)5 6.75 (dd, J= 2.2, 7.9 Hz, IH), 3.80 (s, 3H)5 3.54 (d, J= 7.4 Hz5 2H), 3.41 (t, J= 7.2 Hz5 2H), 3.13 (t, J= 7.2 Hz, 2H)5 2.71 (septet, J= 7.7 Hz, IH), 2.38 (m, 3H), 2.02 (m5 2H), 1.88 (m, 2H)5 1.77 (m, 6H)5 1.62 (m, 2H).

The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IRM LLC; WO2007/87448; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary