Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C7H3BrF4
(1) To a solution of Compound 1 (1 g) and Compound 2 (870 mg) in toluene (2.5 mL) was added a solution of potassium bis(trimethylsilyl)amide in toluene (0.5 mol/L, 8.23 mL) under nitrogen atmosphere at room temperature, and then the mixture was heated under reflux for 15 minutes. To the reaction mixture was poured a saturated aqueous solution of ammonium chloride under ice-cooling, and extracted with ethyl acetate. The organic layer was washed with an aqueous solution of hydrochloric acid (1 mol/L), a saturated aqueous solution of sodium hydrogen carbonate, and saturated saline, dried, and concentrated under reduced pressure. The residue was purified with silica gel column chromatography (hexane:ethyl acetate=90:10-80:20) to give Compound 3 (1.08 g) as a pale yellow viscous material. MS (APCI): m/z 333/335 [M-Boc+H]+
The synthetic route of 68322-84-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary