Adding a certain compound to certain chemical reactions, such as: 17247-58-4, name is (Bromomethyl)cyclobutane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17247-58-4, Product Details of 17247-58-4
Synthesis 9(f)Chemical Formula C16H17NO4 Chemical Formula C21H2JNO4 Chemical Formula C21H27NO4 Exact Mass 287 1 Exact Mass 355 2 Exact Mass 357 2 Molecular Weight 287 3 Molecular Weight 355 4 Molecular Weight 357 4Noroxymorphone N-(CBM)-Noroxymorphone Nalbuphine N-fcyclobutylmethy?-NoroxymorphoneStep 1: Synthesis of N-(cvclobutylmethyl)-Noroxymorphone from Noroxymorphone[0097] Noroxymorphone (1.59 g, 5.5 mmol), potassium carbonate (0.61 g, 6.1 mmol), potassium iodide (0.46 g, 2.8 mmol), and dimethyl acetamide (10 mL) were added into a round bottom flask. Bromomethylcyclobutane (0.82 g, 5.5 mmol, 0.62 mL) was added. The reaction was stirred for 7 days at room temperature. At that time, bromomethylcyclobutane (0.82 g, 5.5 mmol, 0.62 mL) was added. The reaction was stirred for an additional 7 days. HPLC analysis indicated that the noroxymorphone was consumed. Distilled water (50 mL) was added and stirred at room temperature for 6 hours. An off-white precipitate formed, which was removed by filtration. The solid was washed with distilled water (25 mL), then slurried for 24 hours in acetonitrile (25 mL). Filtration, washing the solid with acetonitrile (10 mL), and drying at room temperature under vacuum for 24 hours yielded N-(cyclobutylmethyl)-noroxymorphone (1.43 g, 73% yield) as a tan solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclobutane, and friends who are interested can also refer to it.
Reference:
Patent; MALLINCKRODT INC.; WO2008/137672; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary