Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4333-56-6, name is Bromocyclopropane, A new synthetic method of this compound is introduced below., Formula: C3H5Br
10 mg of Compound 9 was weighed into 5 mL of THF, 5 mg of NaH was added, and the mixture was stirred at room temperature for half an hour. Twenty-fiveBromide cyclopropane, 50 C reaction 6h, TLC detection reaction material almost completely disappeared, adding saturated ammonium chloride to stop the reactionAfter extraction with ethyl acetate twice, the organic layer was dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (eluent EtOAc /Petroleum ether = 20: 1 to 10: 1) to give Compound 11 (9.5 mg) in 85% yield, ESI-MS m / z: 409.2 [M + Na]Ie ^: detection purity of 96.6%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Yangzhou University; Chen Min; Yu Yue; (16 pag.)CN104710396; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary