The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ) is researched.Product Details of 837-52-5.Musonda, Chitalu C.; Little, Susan; Yardley, Vanessa; Chibale, Kelly published the article 《Application of multicomponent reactions to antimalarial drug discovery. Part 3: Discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro》 about this compound( cas:837-52-5 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: aminoquinoline aminoxazole preparation multicomponent reaction antimalarial activity; oxazole amino quinoline preparation multicomponent reaction antimalarial activity. Let’s learn more about this compound (cas:837-52-5).
The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles, e.g. I (R = H, Me; n = 1, 2, 3, 5), against two strains of the Plasmodium falciparum parasite in vitro is described. A number of compounds significantly more potent than the standard drug chloroquine were identified.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary