Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives.Formula: C13H14ClN3.
In an endeavor to develop efficacious antiprotozoal agents 4-(7-chloroquinolin-4-yl)(piperazin-1-yl)(pyrrolidin-2-yl)methanone derivatives were synthesized, characterized, and biol. evaluated for antiprotozoal activity. The compounds were screened in vitro against the HM1: IMSS strain of Entamoeba histolytica and NF54 chloroquine-sensitive strain of Plasmodium falciparum. Among the synthesized compounds, six exhibited promising antiamoebic activity with IC50 values (0.14-1.26 μM) lower than the standard drug metronidazole (IC50 1.80 μM). All nine compounds exhibited antimalarial activity (IC50 range: 1.42-19.62 μM), while maintaining a favorable safety profile to host red blood cells. All the compounds were less effective as an antimalarial and more toxic (IC50 range: 14.67-81.24 μM) than quinine (IC50: 275.6 ± 16.46 μM) against the human kidney epithelial cells. None of the compounds exhibited any inhibitory effect on the viability of Anopheles arabiensis mosquito larvae.
If you want to learn more about this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Formula: C13H14ClN3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(837-52-5).
Reference:
Bromide – Wikipedia,
bromide – Wiktionary