Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Pilot plant production of anti-malarial drug piperaquine phosphate and synthesis of its metabolites.Electric Literature of C13H14ClN3.
An optimized, convergent, safe synthesis of piperaquine phosphate (I), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for I production were made in the preparation of its intermediate by using directly piperazine instead of N-formyl piperazine. The structures of the synthetic compounds were determined from spectral anal. including MS and 2D NMR.
There is still a lot of research devoted to this compound(SMILES：C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3)Electric Literature of C13H14ClN3, and with the development of science, more effects of this compound(837-52-5) can be discovered.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary