Extracurricular laboratory: Synthetic route of 1001-26-9

This literature about this compound(1001-26-9)Product Details of 1001-26-9has given us a lot of inspiration, and I hope that the research on this compound(Ethyl 3-Ethoxy-2-Propenoate) can be further advanced. Maybe we can get more compounds in a similar way.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A new facile synthesis of 2-aminothiazole-5-carboxylates, published in 2001-03-12, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Product Details of 1001-26-9.

A facile method was developed for the synthesis of 2-aminothiazole-5-carboxylates. The method involves reaction of Et β-ethoxyacrylate with N-bromosuccinimide (NBS) to give a novel intermediate, α-bromo-α-formylacetate hemiacetal. Cyclization of the in-situ formed hemiacetal with thioureas afforded 2-aminothiazole-5-carboxylates in 60-98% yields.

This literature about this compound(1001-26-9)Product Details of 1001-26-9has given us a lot of inspiration, and I hope that the research on this compound(Ethyl 3-Ethoxy-2-Propenoate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary