Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids, Author is Lombard, Marli C.; N’Da, David D.; Breytenbach, Jaco C.; Smith, Peter J.; Lategan, Carmen A., which mentions a compound: 837-52-5, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3, Computed Properties of C13H14ClN3.
Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids, which were then treated with oxalic acid to form oxalate salts. Some of the compounds showed comparable potency in vitro to that of chloroquine (CQ) against the chloroquine sensitive (CQS) strain, and were found to be more potent against the chloroquine resistant CQR strain. Hybrid I and its oxalate salt were the most active against CQR strain, being 9- and 7-fold more active than CQ resp. (17.12 nM; 20.76 nM vs. 157.9 nM). An optimum chain length was identified having 2 or 3 Cs with or without an extra methylene substituent.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary