Machine Learning in Chemistry about 837-52-5

From this literature《Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum》,we know some information about this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline, but this is not all information, there are many literatures related to this compound(837-52-5).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum, published in 2007-01-01, which mentions a compound: 837-52-5, Name is 7-Chloro-4-(piperazin-1-yl)quinoline, Molecular C13H14ClN3, Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline.

A targeted series of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives were synthesized and evaluated in vitro against the malarial cysteine protease falcipain-2 and a chloroquine resistant strain (W2) of Plasmodium falciparum. A novel series of 4-aminoquinoline semicarbazones were the most effective inhibitors of falcipain-2 (most potent inhibitor had IC50 = 0.63 μM) while a bisquinoline semicarbazone compound 8f (I) was the most potent antimalarial compound with an IC50 of 0.07 μM against W2. Compound 8f also weakly inhibited falcipain-2, with an IC50 of 3.16 μM, although its principal antiparasitic activity did not appear to be due to inhibition of this enzyme.

From this literature《Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum》,we know some information about this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline, but this is not all information, there are many literatures related to this compound(837-52-5).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary