The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety, the main research direction is oxadiazolylmethylpiperazinyl quinoline derivative preparation antituberculosis; Antitubercular activity; Bioavailability; Cytotoxicity; Oxadiazole; Quinoline.Reference of 7-Chloro-4-(piperazin-1-yl)quinoline.
Tuberculosis is the infectious disease caused by mycobacterium tuberculosis (Mtb), responsible for the utmost number of deaths annually across the world. Herein, twenty-one new substituted 1,2,4-oxadiazol-3-ylmethyl-piperazin-1-yl-quinoline derivatives were designed and synthesized through multistep synthesis followed by in vitro evaluation of their antitubercular potential against Mtb WT H37Rv. The compound I was found to be promising with MIC value of 0.5 μg/mL and QD-19 to QD-21 were also remarkable with MIC value of 0.25 μg/mL. Addnl., we have carried out experiments to confirm the metabolic stability, cytotoxicity and pharmacokinetics of these compounds along with kill kinetics of QD-18. These compounds were found to be orally bioavailable and highly effective. Altogether, these results indicate that I and II (R = 2,3-Me2Ph, cyclopentyl, and 4-iPrPh) are promising lead compounds for the development of a novel chem. class of antitubercular drugs.
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