The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of novel hybrid molecules from precursors with known antiparasitic activity, the main research direction is nitrofuranylpropenoyl nitropyrazole chloropiperazinylquinoline hybrid preparation antiamoebic antigiardial antiparasitic activity.Product Details of 837-52-5.
Novel new compounds I, II, and III derived from antiparasitic precursors were synthesized and tested for their antiamoebic and antigiardial activities. On the basis of preliminary screening data for these new compounds, compound III exhibited potent lethal activities against Entamoeba histolytica and Giardia intestinalis; its IC50 (about 1 μM) was lower, at least by a factor of five, compared to the standard drug, metronidazole. In addition, the IC50 of compound III against the tested parasites was 600 times below that against Hep-2 and Vero cells. Compounds I and II also exhibited potent or moderate antiamoebic and antigiardial activities with IC50 values of about 5.5 μM, and 140 μM, resp., against the tested parasites. Hybrid mols. I and II were also non-cytotoxic at the lethal concentrations against the parasites.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary