Valero, Guillem; Schimer, Jiri; Cisarova, Ivana; Vesely, Jan; Moyano, Albert; Rios, Ramon published the artcile< Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-paroxetine>, SDS of cas: 3893-18-3, the main research area is malonmonoamide unsaturated aldehyde stereoselective cyclization secondary amine catalyst; piperidinone asym synthesis; paroxetine asym formal synthesis.
A highly enantioselective organocatalytic synthesis of piperidines is reported starting from protected malonmonoamides and α,β-unsaturated aldehydes. The reaction is catalyzed by simple and com. available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-paroxetine, a blockbuster drug, in only 3 steps.
Tetrahedron Letters published new progress about Cyclization catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary