Kumar, Mukesh; Chauhan, Pankaj; Valkonen, Arto; Rissanen, Kari; Enders, Dieter published the artcile< Asymmetric Synthesis of Functionalized Tricyclic Chromanes via an Organocatalytic Triple Domino Reaction>, Electric Literature of 3893-18-3, the main research area is asym synthesis functionalized tricyclic chromane organocatalysis triple domino; secondary amine catalyzed domino Michael aldol condensation aldehyde nitrochromene; alpha beta unsaturated aldehyde Michael aldol condensation nitrochromene; crystal mol structure tricyclic chromane.
A highly stereoselective triple domino reaction for the synthesis of functionalized tricyclic chromane scaffolds has been developed. A secondary amine-catalyzed domino Michael/Michael/aldol condensation reaction between aliphatic aldehydes, nitro-chromenes, and α,β-unsaturated aldehydes leads to the formation of synthetically important tricyclic chromanes bearing four contiguous stereogenic centers including a tetrasubstituted carbon in good yields (20-66%) and excellent stereoselectivities (>20:1 dr and >99% ee).
Organic Letters published new progress about Aldol condensation. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary