Lin, Xia; Fang, Chengtao; Huang, Xiaolei; Xiao, Xiaohui published the artcile< 1,1,2-Tribromoethyl arenes: novel and highly efficient precursors for the synthesis of 1-bromoalkynes and α-bromoketones>, Computed Properties of 2725-82-8, the main research area is bromoalkyne bromoketone preparation; tribromoethyl arene preparation elimination reaction; ethylbenzene bromination.
Herein, a novel method to synthesize 1,1,2-tribromoethyl arenes, which can be easily transformed to 1-bromoalkynes via base-mediated elimination reaction is reported. The bromination reagent was in situ generated from the reaction of NaBr/NaBrO3/H2SO4, resulting in high reactivity, excellent chem. selectivity and outstanding functional group tolerance. Moreover, 1,1,2-tribromoethyl arenes encounter a selectivity switch to afford α-bromoketones under strong acidic conditions.
Organic Chemistry Frontiers published new progress about Alkynes, bromo Role: SPN (Synthetic Preparation), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Computed Properties of 2725-82-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary