Yan, Gang; Zekarias, Bereket L.; Li, Xiaoyu; Jaffett, Victor A.; Guzei, Ilia A.; Golden, Jennifer E. published the artcile< Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process>, COA of Formula: C7H6BrNO2, the main research area is chloroquinazolinone preparation; diamine tandem rearrangement heterocyclization; domino; guanidine; quinazolinone; rearrangement; twisted guanidine.
A highly efficient 2-chloroquinazolin-4(3H)-one rearrangement was developed that predictably generated either twisted-cyclic or ring-fused guanidines in a single operation, depending on the presence of a primary vs. secondary amine in the accompanying diamine reagent. Exclusive formation of twisted-cyclic guanidines results from pairing 2-chloroquinazolinones with secondary diamines. Use of primary amine-containing diamines permited a domino quinazolinone rearrangement/intramol. cyclization gated through (E)-twisted-cyclic guanidines to afford ring-fused N-acylguanidines. This scalable, structurally tolerant transformation generated 55 guanidines and delivered twisted-cyclic guanidines with robust plasma stability and an abbreviated total synthesis of an antitumor ring-fused guanidine (4 steps, 55% yield).
Chemistry – A European Journal published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, COA of Formula: C7H6BrNO2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary