Cheng, Xiaokai; Lu, Huangzhe; Lu, Zhan published the artcile< Enantioselective benzylic C-H arylation via photoredox and nickel dual catalysis>, Safety of 3-Bromobenzotrifluoride, the main research area is diaryl alkane enantioselective preparation; alkyl benzene aryl bromide benzylic arylation photoredox catalysis nickel.
Here, an enantioselective benzylic C(sp3)-H bond arylation via photoredox/nickel dual catalysis was reported. Sterically hindered chiral biimidazoline ligands were designed for this asym. cross-coupling reaction. Readily available alkyl benzenes and aryl bromides with various functional groups tolerance could be easily and directly transferred to useful chiral 1,1-diaryl alkanes I [R = Me, Et, Bn, etc.; Ar1 = Ph, 4-MeOC6H4, 4-FC6H4, 4-iBuC6H4, 2-naphthyl; Ar2 = 4-FC6H4, 3-CNC6H4, benzofuran-5-yl, etc.] including pharmaceutical intermediates and bioactive mols. This reaction proceeded smoothly under mild conditions without the use of external redox reagents.
Nature Communications published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (1,1-diaryl alkanes). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Safety of 3-Bromobenzotrifluoride.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary